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Airborne toxicological assessment: The potential of lung-on-a-chip as an alternative to animal testing.

Airborne toxicological assessment: The potential of lung-on-a-chip as an alternative to animal testing.

June 2022.Ko-Chih Lin, Chun-Zai Yen, Jia-Wei Yang, Johnson H.Y Chung and Guan-Yu Chen*.Materials Today Advances.
Recent studies have shown that there exists a direct relationship between environmental pollutants (PM2.5, smog), the respiratory system, and the morbidity and mortality of cardiovascular diseases. However,[...]
A Mask R-CNN Based Automatic Assessment System for Nail Psoriasis Severity.

A Mask R-CNN Based Automatic Assessment System for Nail Psoriasis Severity.

April 2022. Kuan Yu Hsieh, Hung-Yi Chen, Sung-Cheol Kim, Yun-Ju Tsai, Hsien-Yi Chiu* and Guan-Yu Chen*. Computers in Biology and Medicine.
Nail psoriasis significantly impacts the quality of life in patients with psoriasis, which affects approximately 2–3% of the population worldwide. Disease severity measures are essential in guiding treatment and evaluation of[...]
Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity.

Tissue-level alveolar epithelium model for recapitulating SARS-CoV-2 infection and cellular plasticity.

Jan 2022. Jia-Wei Yang, Yu-Rou Lin, Ying-Ling Chu, Johnson H.Y Chung, Huai-En Lu and Guan-Yu Chen*. Communications Biology.
Pulmonary sequelae following COVID-19 pneumonia have been emerging as a challenge; however, suitable cell sources for studying COVID-19 mechanisms and therapeutics are currently lacking. In this paper, we present a standardized[...]
Investigation of the role of the autophagic protein LC3B in the regulation of human airway epithelium cell differentiation in COPD using a biomimetic model.

Investigation of the role of the autophagic protein LC3B in the regulation of human airway epithelium cell differentiation in COPD using a biomimetic model.

January 2022. Shiue-Luen Chen, Hsiao-Chun Chou, Kuan-Chen Lin, Jia-Wei Yang, Ren-Hao Xie, Chong-You Chen, Xin-Yi Liu, Johnson H.Y Chung and Guan-Yu Chen*.Materials Today Bio.
Chronic obstructive pulmonary disease (COPD) is one of the most lethal chronic disease worldwide; however, the establishment of reliable in vitro models for exploring the biological mechanisms of COPD remains challenging. Here, we determined the[...]
Development of an alveolar chip model to mimic respiratory conditions due to fine particulate matter exposure.

Development of an alveolar chip model to mimic respiratory conditions due to fine particulate matter exposure.

March 2022. Ko-Chih Lin, Jia-Wei Yang, Pei-Yi Ho, Chun-Zai Yen, Hao-Wei Huang, Hsuan-Yu Lin, Johnson Chung and Guan-Yu Chen*. Applied Materials Today.
Fine particulate matter (PM) is traditionally known to cause respiratory diseases such as chronic obstructive pulmonary disease. Once inhaled into the lungs, airborne fine PM is transferred into the blood circulation and transported via blood [...]
The Development of Controllable Magnetic Driven Microphysiological System.

The Development of Controllable Magnetic Driven Microphysiological System.

Nov 2019. Jia-Wei Yang, Yu-Wei Chen, Pei-Yi Ho, Liane Jiang, Sheng-Jen Cheng, Ko-Chih Lin, Kuan Yu Hsieh, Huai-En Lu, Hsien-Yi Chiu, Shien-Fong Lin and Guan-Yu Chen*.Frontiers in Cell and Developmental Biology.
Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions[...]
Organ-on-a-chip: Opportunities for assessing the toxicity of particulate matter.

Organ-on-a-chip: Opportunities for assessing the toxicity of particulate matter.

May 2020. Jia-Wei Yang, Yu-Chih Shen, Ko-Chih Lin, Sheng-Jen Cheng, Shiue-Luen Chen, Chong-You Chen, Priyank V Kumar, Shien-Fong Lin, Huai-En Lu* and Guan-Yu Chen*. Frontiers in Bioengineering and Biotechnology.
Recent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many [...]

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