June 2022.Ko-Chih Lin, Chun-Zai Yen, Jia-Wei Yang, Johnson H.Y Chung and Guan-Yu Chen*.Materials Today Advances. Recent studies have shown that there exists a direct relationship between environmental pollutants (PM2.5, smog), the respiratory system, and the morbidity and mortality of cardiovascular diseases. However,[...]
April 2022. Kuan Yu Hsieh, Hung-Yi Chen, Sung-Cheol Kim, Yun-Ju Tsai, Hsien-Yi Chiu* and Guan-Yu Chen*. Computers in Biology and Medicine. Nail psoriasis significantly impacts the quality of life in patients with psoriasis, which affects approximately 2–3% of the population worldwide. Disease severity measures are essential in guiding treatment and evaluation of[...]
Jan 2022. Jia-Wei Yang, Yu-Rou Lin, Ying-Ling Chu, Johnson H.Y Chung, Huai-En Lu and Guan-Yu Chen*. Communications Biology. Pulmonary sequelae following COVID-19 pneumonia have been emerging as a challenge; however, suitable cell sources for studying COVID-19 mechanisms and therapeutics are currently lacking. In this paper, we present a standardized[...]
January 2022. Shiue-Luen Chen, Hsiao-Chun Chou, Kuan-Chen Lin, Jia-Wei Yang, Ren-Hao Xie, Chong-You Chen, Xin-Yi Liu, Johnson H.Y Chung and Guan-Yu Chen*.Materials Today Bio. Chronic obstructive pulmonary disease (COPD) is one of the most lethal chronic disease worldwide; however, the establishment of reliable in vitro models for exploring the biological mechanisms of COPD remains challenging. Here, we determined the[...]
March 2022. Ko-Chih Lin, Jia-Wei Yang, Pei-Yi Ho, Chun-Zai Yen, Hao-Wei Huang, Hsuan-Yu Lin, Johnson Chung and Guan-Yu Chen*. Applied Materials Today. Fine particulate matter (PM) is traditionally known to cause respiratory diseases such as chronic obstructive pulmonary disease. Once inhaled into the lungs, airborne fine PM is transferred into the blood circulation and transported via blood [...]
Nov 2019. Jia-Wei Yang, Yu-Wei Chen, Pei-Yi Ho, Liane Jiang, Sheng-Jen Cheng, Ko-Chih Lin, Kuan Yu Hsieh, Huai-En Lu, Hsien-Yi Chiu, Shien-Fong Lin and Guan-Yu Chen*.Frontiers in Cell and Developmental Biology. Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions[...]
May 2020. Jia-Wei Yang, Yu-Chih Shen, Ko-Chih Lin, Sheng-Jen Cheng, Shiue-Luen Chen, Chong-You Chen, Priyank V Kumar, Shien-Fong Lin, Huai-En Lu* and Guan-Yu Chen*. Frontiers in Bioengineering and Biotechnology. Recent developments in epidemiology have confirmed that airborne particulates are directly associated with respiratory pathology and mortality. Although clinical studies have yielded evidence of the effects of many [...]
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